АвторТема: Когнитивные способности  (Прочитано 1262 раз)

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Когнитивные способности
« : 23 Февраль 2017, 08:32:21 »
Holocene selection for variants associated with cognitive ability: Comparing ancient and modern genomes.

Michael A Woodley of Menie, Shameem Younuskunja, Bipin Balan, Davide Piffer


Human populations living in Eurasia during the Holocene experienced significant evolutionary change. It has been predicted that the transition of Holocene populations into agrarianism and urbanization brought about culture-gene co-evolution that favoured via directional selection genetic variants associated with higher general cognitive ability (GCA). Population expansion and replacement has also been proposed as an important source of GCA gene-frequency change during this time period. To examine whether GCA might have risen during the Holocene, we compare a sample of 99 ancient Eurasian genomes (ranging from 4,557 to 1,208 years of age) with a sample of 503 modern European genomes, using three different cognitive polygenic scores. Significant differences favouring the modern genomes were found for all three polygenic scores (Odds Ratio=0.92, p=0.037; 0.81, p=0.001 and 0.81, p=0.02). Furthermore, a significant increase in positive allele count over 3,249 years was found using a sample of 66 ancient genomes (r=0.217, p one-tailed=0.04). These observations are consistent with the expectation that GCA rose during the Holocene.



© 2007 Молекулярная Генеалогия (МолГен)

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