Стали доступны тезисы конференции SMBE 2018:
http://smbe2018.jp/mobile_app.html#abstract_pdfНекоторые интересные доклады/постеры:
Геном представителя охотской культуры из Северной Японии, мтДНК G1b:
Human population history in the southwestern coastal region of Sea of Okhotsk, inferred from ancient genome analysis
Takehiro Sato 1, Noboru Adachi 2, Ryosuke Kimura 3, Minoru Yoneda 4, Hiroki Oota 5, Atsushi Tajima 1, Atsushi Toyoda 6, Hiromi Matsumae 7, 8, Kae Koganebuchi 3, Kentaro K Shimizu 7, 8, Tsunehiko Hanihara 4, Andrzej Weber 9, Hirofumi Kato 10, Hajime Ishida 3
1 Kanazawa University (Japan),
2 University of Yamanashi (Japan),
3 University of the Ryukyus (Japan),
4 The University of Tokyo (Japan),
5 Kitasato University (Japan),
6 National Institute of Genetics (Japan),
7 University of Zurich (Switzerland),
8 Yokohama City University (Japan),
9 University of Alberta (Canada),
10 Hokkaido University (Japan)
In 2013, an ancient human skeleton (NAT002) of the prehistoric Okhotsk culture was excavated from Hamanaka 2 site, Rebun Island, northern Japan. Radiocarbon age of NAT002 was 1060-1155 (68.2%) calAD. Some bones of this individual were affected by severe hyperostosis, suggesting SAPHO syndrome. To investigate the genetic features of the Okhotsk people, we extracted DNA from 3rd molars of NAT002 and performed whole genome sequencing. As a result of sequencing for 18 NGS libraries, the sequence data with 35-fold coverage was obtained. The typical deamination pattern and sufficiently low contamination rate were observed, ensuring the DNA authenticity. The mtDNA haplotype of NAT002 was assigned to haplogroup G1b, which is commonly observed among the modern North Asian populations. Results of outgroup f3 test, PCA, and ADMIXTURE analysis indicated that NAT002 was genetically close to the modern Nivkh and Ulch, who are living around the northern Sakhalin and the Lower Amur Basin. In addition, TREEMIX analysis indicated gene flow from the Ainu to NAT002. These findings suggest the past human migration from the Lower Amur region to the northern part of the Japanese archipelago and the admixture between the Okhotsk and Ainu lineages, corresponding to the archaeological evidences. HLA typing indicated that NAT002 possessed HLA-B40 allele, which has been reported as one of the risk factors of ankylosing spondylitis, reactive arthritis, and undifferentiated spondyloarthritis. These diseases are classified into seronegative arthritis as well as SAPHO syndrome. Therefore, HLA type of NAT002 might be one of the cause of the hyperostosis.
50 древних геномов из Ирландии, от мезолита, до бронзового века:
The Genomics of Megaliths: An Irish case study into the reconstruction of prehistoric societal landscapes through ancient DNA analysis
Lara M Cassidy 1
1 Trinity College Dublin (Ireland)
The Irish Neolithic (circa 3,800-2,500) marks the emergence of complex civilization on the island, alongside the establishment of continued contacts with other Atlantic regions, which intensify in the succeeding Copper and Bronze Ages. In addition to these cultural upheavals, the Neolithic period has been demonstrated to both begin and end with mass migration into the island, potentially from multiple external sources. However, the variable interplay between geography and culture in the catalyzation of these population movements has remained an open question. Indeed, the archaeological record would suggest regional heterogeneity in the uptake of British and continental traditions at both transition points.
Here, the potential social and cultural implications of such events are explored through the prism of ancient genomics. Imputed diploid genotypes for over 50 individuals sampled from the Mesolithic to Bronze Age periods, encompassing a diversity of megalithic structures, are presented and dissected through the use of haplotypic-sharing methods, as well as estimations of kinship and inbreeding. Combined with Y chromosome analysis these provide the first evidence of genetic structure on the island during specific prehistoric time intervals, which can be interpreted along both geographical and cultural lines. Furthermore, candidate refugiums that may recurrently act as reservoirs for older traditions and genetic ancestries are identified, as well as hub regions, which appear more susceptible to demographic disturbances on the continent, highlighting the immovable constraints of geography on both cultural and genomic evolution.
Тема: Re: Результаты исследований дДНК (обсуждение) (Прочитано 768454 раз)