АвторТема: Natural Selection Reduced Diversity on Human Y Chromosomes  (Прочитано 1183 раз)

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Natural Selection Reduced Diversity on Human Y Chromosomes
« : 18 Январь 2014, 10:01:20 »
Natural Selection Reduced Diversity on Human Y Chromosomes.

Melissa A. Wilson Sayres, Kirk E. Lohmueller, Rasmus Nielsen.

Published: January 09, 2014.

Abstract

The human Y chromosome exhibits surprisingly low levels of genetic diversity. This could result from neutral processes if the effective population size of males is reduced relative to females due to a higher variance in the number of offspring from males than from females. Alternatively, selection acting on new mutations, and affecting linked neutral sites, could reduce variability on the Y chromosome. Here, using genome-wide analyses of X, Y, autosomal and mitochondrial DNA, in combination with extensive population genetic simulations, we show that low observed Y chromosome variability is not consistent with a purely neutral model. Instead, we show that models of purifying selection are consistent with observed Y diversity. Further, the number of sites estimated to be under purifying selection greatly exceeds the number of Y-linked coding sites, suggesting the importance of the highly repetitive ampliconic regions. While we show that purifying selection removing deleterious mutations can explain the low diversity on the Y chromosome, we cannot exclude the possibility that positive selection acting on beneficial mutations could have also reduced diversity in linked neutral regions, and may have contributed to lowering human Y chromosome diversity. Because the functional significance of the ampliconic regions is poorly understood, our findings should motivate future research in this area.

http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1004064

 

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