Y-chromosome O3 Haplogroup Diversity in Sino-Tibetan Populations Reveals Two Mig

[sahaliyan]

Longli Kang et al
The eastern Himalayas are located near the southern entrance through which early modern humans expanded into East Asia. The genetic structure in this region is therefore of great importance in the study of East Asian origins. However, few genetic studies have been performed on the Sino-Tibetan populations (Luoba and Deng) in this region. Here, we analyzed the Y-chromosome diversity of the two populations. The Luoba possessed haplogroups D, N, O, J, Q, and R, indicating gene flow from Tibetans, as well as the western and northern Eurasians. The Deng exhibited haplogroups O, D, N, and C, similar to most Sino-Tibetan populations in the east. Short tandem repeat (STR) diversity within the dominant haplogroup O3 in Sino-Tibetan populations showed that the Luoba are genetically close to Tibetans and the Deng are close to the Qiang. The Qiang had the greatest diversity of Sino-Tibetan populations, supporting the view of this population being the oldest in the family. The lowest diversity occurred in the eastern Himalayas, suggesting that this area was an endpoint for the expansion of Sino-Tibetan people. Thus, we have shown that populations with haplogroup O3 moved into the eastern Himalayas through at least two routes.

http://onlinelibrary.wiley.com/doi/10.1111/j.1469-1809.2011.00690.x/abstract

[I2a1a]

非常感谢您

[sahaliyan]

http://onlinelibrary.wiley.com/doi/10.1111/j.1469-1809.2011.00690.x/suppinfo
Table S1 General information of the population samples analyzed in this paper.

Table S2 SNP haplogroups and STR diversities of Luoba and Deng.

Figure S1 STR networks for the O3 samples of the East Asians.

Figure S2 O3-M117 STR structure of the East Asians estimated by STRUCTURE software.

Figure S3 O3-M134 STR structure of the East Asians estimated by STRUCTURE software.

Filename Format Size Description
AHG_690_sm_SFig1.gif  559K Supporting info item
AHG_690_sm_SFig2.gif  4815K Supporting info item
AHG_690_sm_SFig3.gif  1930K Supporting info item
AHG_690_sm_STab1.xls  38K Supporting info item
AHG_690_sm_STab2.xls  53K Supporting info item

Please note: Wiley-Blackwell are not responsible for the content or functionality of any supporting materials supplied by the authors. Any queries (other than missing material) should be directed to the corresponding author for the article.

[Nimissin]

Уважаемый Mouglley, обратите внимание:
Лоба (Luoba), Восточные Гималаи
D* 1/109 = 0.9 %
D1-M15 2/109 = 1.8 %
D3a-P47 17/109 = 15.6 %
J-M304 1/109 = 0.9 %
N1-LLY22g 39/109 = 35.8 %
O*-M175 2/109 = 1.8 %
O3*-M122 1/109 = 0.9 %
O3a3c*-M134 3/109 = 2.8 %
O3a3c1-M117 33/109 = 30.3 %
Q-M242 1/109 = 0.9 %
R*-M306 3/109 = 2.8 %
R1-M173 1/109 = 0.9 %
R1a1-M17 5/109 = 4.6 %

http://ru.wikipedia.org/wiki/%CB%EE%E1%E0_(%ED%E0%F0%EE%E4)

[Nimissin]

При более внимательном рассмотрении оказалось, что гаплотипы  R*-M306 на самом деле R2-M124

[mouglley]

Я так вижу, что они проверяли по снипам: (Haplogroup N), M231, M214, LLY22g, M128, M46/Tat, P63, P119, P105, P43, M178.
А нашли только LLY22g.
То есть N1*.


По предиктору:
Sample   Hg   SNP   Haplogroup   Probability
DB98   N1*   LLY22g   Q1a-MEH2   94%
LB106   N1*   LLY22g   R1b-M343   51%
LB107   N1*   LLY22g   Q1a-MEH2   86%
LB108   N1*   LLY22g   P-M45   93%
LB129   N1*   LLY22g   Q1a-MEH2   92%
LB131   N1*   LLY22g   Q1a-MEH2   93%
LB132   N1*   LLY22g   Q1a-MEH2   92%
LB133   N1*   LLY22g   Q1a-MEH2   93%
LB134   N1*   LLY22g   Q1a-MEH2   92%
LB136   N1*   LLY22g   Q1a-MEH2   93%
LB149   N1*   LLY22g   Q1a-MEH2   93%
LB151   N1*   LLY22g   Q1a-MEH2   92%
LB159   N1*   LLY22g   Q1a-MEH2   89%
LB160   N1*   LLY22g   Q1a-MEH2   92%
LB166   N1*   LLY22g   Q1a-MEH2   92%
LB173   N1*   LLY22g   Q1a-MEH2   98%
LB194   N1*   LLY22g   Q1a-MEH2   92%
LB200   N1*   LLY22g   R1b1*-P25*(xP297)   59%
LB216   N1*   LLY22g   Q1a-MEH2   92%
LB217   N1*   LLY22g   Q1a-MEH2   92%
LB219   N1*   LLY22g   _IJ-M429   72%
LB232   N1*   LLY22g   Q1a-MEH2   61%
LB240   N1*   LLY22g   Q1a-MEH2   61%
LB241   N1*   LLY22g   Q1a-MEH2   92%
LB243   N1*   LLY22g   Q-M242   97%
LB244   N1*   LLY22g   Q1a-MEH2   78%
LB249   N1*   LLY22g   Q1a-MEH2   98%
LB260   N1*   LLY22g   Q1a-MEH2   92%
LB264   N1*   LLY22g   Q1a-MEH2   94%
LB272   N1*   LLY22g   Q1a-MEH2   92%
LB285   N1*   LLY22g   Q1a-MEH2   82%
LB290   N1*   LLY22g   P-M45   93%
LB291   N1*   LLY22g   Q1a-MEH2   92%
LB293   N1*   LLY22g   Q1a-MEH2   82%
LB306   N1*   LLY22g   Q1a-MEH2   92%
LB324   N1*      Q1a-MEH2   98%
LB341   N1*   LLY22g   J2a-M410   55%
LB344   N1*   LLY22g   O3-M122   75%
LB345   N1*   LLY22g   Q1a-MEH2   92%
LB348   N1*   LLY22g   Q1a-MEH2   94%

[Nimissin]

Предиктор не обучен еще.

[mouglley]

Уважаемый Mouglley, обратите внимание:
Лоба (Luoba), Восточные Гималаи
N1-LLY22g 39/109 = 35.8 %

Максимальные значения N1* в мире.

[mouglley]

DYS385-a=12, DYS438=11, DYS393=13, DYS439=12, DYS388=14, DYS426=12 у N1c1 редкость.

[Nimissin]

Полагаю, что DYS388 все же равен 12. Локус измерен в какой-то другой системе с отличием +2.

[sahaliyan]

Предиктор не обучен еще.

It seems there are some error in their STR work,for example,all their DYS426 of O is 12(should be 11 instead),and their DYS426 of R,Q is 13

[Nimissin]

Предиктор не обучен еще.

It seems there are some error in their STR work,for example,all their DYS426 of O is 12(should be 11 instead),and their DYS426 of R,Q is 13

You are right.

[sahaliyan]

It seems M134* is very low frequecy in most Sino-Tibetan population,but Tangut-Qiangic population and northern Han Chinese is exception,I'm very interested in the origin of this branch

[Centurion]

Каково разнообразие этих N1*?

[sahaliyan]

Current N1(XN1a,N1b,N1c)
Luoba 39/109 = 35.8 %
Yi of Sichuan 13/43= 30.2%
Han of Guangdong 6/40=15.0%
Hani   4/34=11.8%
Xibe  4/41=9.8%
Han of Shanxi  3/44=6.8%
Tujia  2/49=4.1%
Manchu
2/52=3.8%
2/35=5.7%
Han of Taiwan  3/84=3.6%
Uyghurs
2/70=2.9%
2/67=3%