Genetic structure of Jewish populations on the basis of genome-wide single nucleotide polymorphisms.
N. M. Kopelman
The Jewish population forms a genetically structured population, due to historical migrations and diverse histories of the various Jewish communities. Discerning the ancestry and population structure of different Jewish populations is important for understanding the complex history of the Jewish communities as well as for research on the genetic basis of disease. Using >500,000 genome-wide single-nucleotide polymorphisms, we investigated patterns of population structure in 438 samples from 30 Jewish populations in the context of additional samples from non-Jewish populations. The collection of Jewish populations studied incorporates a variety of populations not previously included in other genomic population structure studies of Jewish groups (e.g. NM Kopelman et al. 2009 BMC Genet 10:80; G Atzmon et al. 2010 AJHG 86:850-859; DM Behar et al. 2010 Nature 466:238-242; SM Bray et al. 2010 PNAS 107:16222-16227; JB Listman et al. 2010 BMC Genet 11:48). We identify fine-scale population structure within the Jewish samples, including notable distinctions separating Ashkenazi, Mizrahi, Sephardi, and North African populations. Additionally, we identify distinctions within major regional groups, including a separation among the North African populations of Libyan, Moroccan, and Tunisian Jewish samples and a separation among the Mizrahi populations of Bukharan, Georgian, Iranian, and Iraqi Jewish samples. These results supply enhanced information regarding Jewish population structure, providing a basis for further detailed analysis of the genetic history of Jewish populations.
Hopefully the wealth of this new Jewish and non-Jewish data will be made publicly available.
http://www.ichg2011.org/abstracts/fulltext/
Тема: Genetic structure of Jewish populations on the basis of genome-wide SNP (Прочитано 1968 раз)