Whole-genome sequencing of 175 Mongolians uncovers population-specific genetic architecture and gene flow throughout North and East Asia
Haihua Bai, Xiaosen Guo, Narisu Narisu, Tianming Lan, Qizhu Wu, Yanping Xing, Yong Zhang, Stephen R. Bond, Zhili Pei, Yanru Zhang, Dandan Zhang, Jirimutu Jirimutu, Dong Zhang, Xukui Yang, Morigenbatu Morigenbatu, Li Zhang, Bingyi Ding, Baozhu Guan, Junwei Cao, Haorong Lu, Yiyi Liu, Wangsheng Li, Ningxin Dang, Mingyang Jiang, Shenyuan Wang, Huixin Xu, Dingzhu Wang, Chunxia Liu, Xin Luo, Ying Gao, Xueqiong Li, Zongze Wu, Liqing Yang, Fanhua Meng, Xiaolian Ning, Hashenqimuge Hashenqimuge, Kaifeng Wu, Bo Wang, Suyalatu Suyalatu, Yingchun Liu, Chen Ye, Huiguang Wu, Kalle Leppälä, Lu Li, Lin Fang, Yujie Chen, Wenhao Xu, Tao Li, Xin Liu, Xun Xu, Christopher R. Gignoux, Huanming Yang, Lawrence C. Brody, Jun Wang, Karsten Kristiansen, Burenbatu Burenbatu,
Huanmin Zhou, Ye Yin
Abstract
The genetic variation in Northern Asian populations is currently undersampled. To address this, we generated a new genetic variation reference panel by whole-genome sequencing of 175 ethnic Mongolians, representing six tribes. The cataloged variation in the panel shows strong population stratification among these tribes, which correlates with the diverse demographic histories in the region. Incorporating our results with the 1000 Genomes Project panel identifies derived alleles shared between Finns and Mongolians/Siberians, suggesting that substantial gene flow between northern Eurasian populations has occurred in the past. Furthermore, we highlight that North, East, and Southeast Asian populations are more aligned with each other than these groups are with South Asian and Oceanian populations.
http://www.nature.com/articles/s41588-018-0250-5В работе есть и сведения о гаплогруппах игрек-хромосомы.
Тема: Whole-genome sequencing of 175 Mongolians (Прочитано 2518 раз)