АвторТема: Две презентации исследований по Средней Азии на ESHG 2017  (Прочитано 1074 раз)

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Анонсированы две презентации исследований игрек-хромосомы в Средней Азии на конференции ESHG 2017.

1. http://www.abstractsonline.com/Plan/ViewAbstract.aspx?sKey=d3a9b800-a5bb-4c52-afa7-94a4a0d2c056&cKey=e7aaedc4-ddad-45e1-a80c-b8fd45ba2f97&mKey=15a3630e-7769-4d64-a80a-47f190ac2f4f

The migrations and barriers that shaped the Central AsianY-chromosomal pool.

O. Balanovsky1,2, M. Zhabagin3, V. Zaporozhchenko1, I. Alborova4, O. Balaganskaya1, A. Agdzhoyan1,2, K. Dibirova2, Y. Yusupov5, Z. Sabitov6, M. Lavryashina7, P. Nymadawa8, Z. Isakova9, K. Mustafin4, C. Tyler-Smith10, E. Balanovska2

Abstract: Central Asia is a contact region in between all other parts of Eurasia, but its Y-chromosomal landscape is very understudied. To compensate for this bias, we first genotyped 5,295 Y-chromosomes from 64 populations representing Mongolia, Russia, Kazakhstan, Uzbekistan, Tajikistan, and Kirgizia. Analysis at the common level of phylogenetic resolution (50 Y-SNPs and 17 Y-STRs) revealed Mongol-Kazakh, Altaian-Uralic, and Persian clusters of populations. Cartographic analysis revealed that a core Central Asian Y-chromosomal pool (centered in Mongolia) spread westward as a narrow stream between the Tian-Shan and Altay mountains, and became much more pronounced in nomads from the lowlands than from the mountains. Thus mountain chains served as one important factor structuring the paternal lineage pool in Central Asia. In phase two of our study, we focused on the major Central Asian haplogroup C2 (formerly C3)-M217. We sequenced 62 Y-chromosomes (~11 Mb each) and constructed a detailed phylogenetic tree. Remarkably, six independent branches expanded simultaneously around 1,000 years ago, indicatingrapid male demographic growth on the eve of the Mongol expansion. We genotyped 1,490 M217-positive samples using 23 branch-defining SNPs discovered in our study, and reconstructed the complex picture of haplogroup C2 branch spread across Central Asia and Siberia. Finally, we observed that barriers between clans were more important for structuring the Central Asian Y-chromosomal pool than geographic barriers. This study was supported by the RSF grant 14-14-00827 (Y-chromosomal sequencing) and the Vavilov Institute for General Genetics theme 0112-2016-0006 (gene pool structure analysis). 

Основное внимание уделено исследованию гаплогруппы C-M217, что вполне обоснованно.

2. http://www.abstractsonline.com/Plan/ViewAbstract.aspx?sKey=d3a9b800-a5bb-4c52-afa7-94a4a0d2c056&cKey=c7a7e7c5-0f9c-41b8-b244-3ead4af0a73a&mKey=15a3630e-7769-4d64-a80a-47f190ac2f4f

The lack of relationship between genetic and geographic distances in the paternal lineages pool of Mawarannahr.

M. Zhabagin1, O. Balanovsky2,3, Z. Sabitov4, A. Agdzhoyan2,3, R. Skhalyakho3,2, S. Turdikulova5, E. Balanovska3

Abstract: Mawarannahr is a historical region of Central Asia, known in Roman sources as Transoxiana. Geographically, it lies in the basins of the two rivers - Amu Darya and Syr Darya. The riversides are densely populated by Kazakhs, Uzbeks, Karakalpaks, Kyrgyz and Turkmens. Culturally, it is region preserving the two distinct modes of subsistence with contrasting traditional cultures - settled agriculture and nomadic pastoralism. To determine the driving forces that shaped the Mawarannahr’s paternal pool, we genotyped 780 samples from 10 populations - 4 regional Kazakh populations, 3 regional Uzbek populations, Karakalpaks, Turkmens and Dungans - by 35 phylogenetically informative Y-chromosomal SNPs and 17 Y-STRs. AMOVA revealed that genetic differentiation between farmers and nomads was three times higher than between geographic groups of the same populations. This observation proves that in contrast to many other regions of the world, in Mawarannahr the cultural landscape shapes gene pool more evidently than geographic landscape. In additional, taking into consideration the fact that the key element of Mawarannahr‘s populations is the clan structure prevalent among nomadic populations, we studied a phylogenetic networks of each clans. Sayeds - a lineages within the Kozha and Sunak clans which are traditionally considered as descendants of the first Islamic missionaries - do not have a predominant paternal common ancestor. Instead, many separate individual haplotypes, or sometimes mini-clusters, can be observed. This study aims was devoted to the genetic landscape of Mawarannahr and supported by funding grants MES RK [[unable to display character: №]]0114[[unable to display character: Р]][[unable to display character: К]]00492 and Presidium RAS Programme “Gene pool dynamycs’ project 0112-2015-0007. 

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