АвторТема: The Great Migration and African-American Genomic Diversity  (Прочитано 540 раз)

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The Great Migration and African-American Genomic Diversity

Soheil Baharian, Maxime Barakatt, Christopher R. Gignoux, Suyash Shringarpure, Jacob Errington, William J. Blot, Carlos D. Bustamante, Eimear E. Kenny, Scott M. Williams, Melinda C. Aldrich, Simon Gravel.

Published: May 27, 2016
http://dx.doi.org/10.1371/journal.pgen.1006059

Abstract

We present a comprehensive assessment of genomic diversity in the African-American population by studying three genotyped cohorts comprising 3,726 African-Americans from across the United States that provide a representative description of the population across all US states and socioeconomic status. An estimated 82.1% of ancestors to African-Americans lived in Africa prior to the advent of transatlantic travel, 16.7% in Europe, and 1.2% in the Americas, with increased African ancestry in the southern United States compared to the North and West. Combining demographic models of ancestry and those of relatedness suggests that admixture occurred predominantly in the South prior to the Civil War and that ancestry-biased migration is responsible for regional differences in ancestry. We find that recent migrations also caused a strong increase in genetic relatedness among geographically distant African-Americans. Long-range relatedness among African-Americans and between African-Americans and European-Americans thus track north- and west-bound migration routes followed during the Great Migration of the twentieth century. By contrast, short-range relatedness patterns suggest comparable mobility of ∼15–16km per generation for African-Americans and European-Americans, as estimated using a novel analytical model of isolation-by-distance.

http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1006059

 

© 2007 Молекулярная Генеалогия (МолГен)

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