АвторТема: Haplotype frequencies at the DRD2 locus in populations of the East European Plai  (Прочитано 1667 раз)

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Haplotype frequencies at the DRD2 locus in populations of the East European Plain Olga V Flegontova , Andrey V Khrunin , Olga I Lylova , Larisa A Tarskaia , Victor A Spitsyn , Alexey I Mikulich  and Svetlana A Limborska
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Abstract (provisional)

Background

It was demonstrated previously that the three-locus RFLP haplotype, TaqI B-TaqI D-TaqI A (B-D-A), at the DRD2 locus constitutes a powerful genetic marker and probably reflects the most ancient dispersal of anatomically modern humans.
Results

We investigated TaqI B, BclI, MboI, TaqI D, and TaqI A RFLPs in 17 contemporary populations of the East European Plain and Siberia. Most of these populations belong to the Indo-European or Uralic language families. We identified three common haplotypes, which occurred in more than 90% of chromosomes investigated. The frequencies of the haplotypes differed according to linguistic and geographical affiliation.
Conclusions

Populations in the northwestern (Byelorussians from Mjadel'), northern (Russians from Mezen' and Oshevensk), and eastern (Russians from Puchezh) parts of the East European Plain had relatively high frequencies of haplotype B2-D2-A2, which may reflect admixture with Uralic-speaking populations that inhabited all of these regions in the Early Middle Ages.

 

© 2007 Молекулярная Генеалогия (МолГен)

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