АвторТема: L1c2b1a, the (African) Haplogroup With The Longest Mitochondrial Genome!  (Прочитано 2538 раз)

0 Пользователей и 1 Гость просматривают эту тему.

Оффлайн Аббат БузониАвтор темы

  • ...
  • Сообщений: 19888
  • Страна: ru
  • Рейтинг +1818/-60
  • Y-ДНК: I1-SHTR7+
  • мтДНК: H16-a1-T152C!
L1c2b1a, the (African) Haplogroup With The Longest Mitochondrial Genome!
K. H. Ritchie, U. A. Perego, A. Achilli, N. R. Angerhofer, N. M. Myres, A. Torroni, S.R. Woodward

Abstract

Haplotypes derived from the maternally-inherited mitochondrial DNA (mtDNA) control region are often employed as a first step in determining phylogenetic-relevant samples that could be selected for additional coding region testing. Using the currently defined world mtDNA haplogroup tree, researchers can assign these haplotypes to specific branches, paying particular attention to novel mutations that could assist in identifying new subclades. Because of the high mutation
rate characteristic of the mtDNA hypervariable region, recurrent and back mutations are observed frequently and therefore some haplogroups are more difficult to predict with these data only. However, several haplogroups have been confirmed through mutations in the control region, such as the Native American C1b branch characterized by the transition at np 493. During a recent survey of the nearly 58000 mtDNA control region haplotypes currently available in the publicly accessible Sorenson Molecular Genealogy Foundation database, we observed a small number of mtDNAs (n=16) characterized by the presence of unusually long insertions. A small subset of these particularly long mtDNA haplotypes shared an identical insertion of 15 bases. Genealogical analysis combined with haplogroup prediction confirmed that these haplotypes shared a common African origin. Additionally, based on the pedigree data gathered, we determine the donors were not closely related. Moreover, through the analysis of complete mtDNA sequences, we conclude that the newly defined haplogroup is most likely of recent origin. As reported in this study, insertions of more than 10 bps are quite rare in the general population and in the published literature, thus providing an interesting case work in population and possibly future disease studies.

http://www.smgf.org/resources/papers/ASHG2008_4.pdf

Оффлайн Asmat headhunter

  • Биохимическая субстанция
  • Сообщений: 14452
  • Страна: id
  • Рейтинг +939/-34
  • И того казака те тунгусы пальмами тут искололи
Re: L1c2b1a, the (African) Haplogroup With The Longest Mitochondrial Genome!
« Ответ #1 : 03 Сентябрь 2009, 20:47:09 »
Что-то мне подсказывает, что не пройдёт и года, как они найдут ещё более длинный геном...  :o

 

© 2007 Молекулярная Генеалогия (МолГен)

Внимание! Все сообщения отражают только мнения их авторов.
Все права на материалы принадлежат их авторам (владельцам) и сетевым изданиям, с которых они взяты.