АвторТема: Variability of the 3ApoB Minisatellite Locus in Eastern Slavonic Populations  (Прочитано 1898 раз)

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Variability of the 3'ApoB Minisatellite Locus in Eastern Slavonic Populations
Dmitry A. Verbenko A.N. Knjazev A.I. Mikulich E.K. Khusnutdinova N.A. Bebyakova S.A. Limborska

Abstract
Objective: To describe and compare the 3apolipoprotein (Apo) B minisatellite allele frequency distributions of Eastern Slavonic populations and their Uralic, Altaic, and Caucasian speaking neighbors. Methods: Healthy individuals of 10 populations among Russians, Byelorussians,
Komis and Bashkirs were studied for variable number tandem repeats (VNTRs) in the 3'ApoB minisatellite region. Data were analyzed with other results reported for this polymorphism in eastern Europeans and Siberians. Results: Allele frequency spectra in Eastern Slavonic, Northern Caucasian and Finno-Ugric speaking populations are bimodal with the main peak in alleles 34–36 and a secondary mode around allele 48, whereas Altaic speaking populations have a unimodal allele frequency distribution with a peak of around 34–36 VNTRs. Population relationships were revealed using both multidimensional scaling analysis (based on Nei’s genetic distance estimate) and testing for genetic heterogeneity. Eastern Slavonic populations (Russians, Ukrainians,
Byelorussians) were most closely related to each other and formed a separate tight cluster when plotted. Testing for genetic heterogeneity among the Eastern Slavonic ethnic groups revealed maximum diversity among Byelorussians, followed by Russians, then Ukrainians. The 3'ApoB minisatellite variability reveals little heterogeneity among the Eastern Slavonic ethnic groups,
whereas there was signifi cant heterogeneity for Northern Caucasian and Altaic speakers. Conclusion: For this 3'ApoB polymorphism the Eastern Slavonic populations, despite their wide geographical distribution, appear to be much more homogenous than other ethnic groups of the region. Multidimensional scaling analysis of these data allowed for differentiation between individual populations from an ethnic group even if there is little heterogeneity.





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