АвторТема: People of the British Isles: preliminary analysis of genotypes and surnames in a  (Прочитано 1334 раз)

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  • 100% Earth (Solar System) genofond
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  • *****
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People of the British Isles: preliminary analysis of genotypes and surnames in a UK-control population // European Journal of Human Genetics advance online publication 10 August 2011;   doi:10.1038/ejhg.2011.127

Winney et al.

There is a great deal of interest in a fine-scale population structure in the UK, both as a signature of historical immigration events and because of the effect population structure may have on disease association studies. Although population structure appears to have a minor impact on the current generation of genome-wide association studies, it is likely to have a significant part in the next generation of studies designed to search for rare variants. A powerful way of detecting such structure is to control and document carefully the provenance of the samples involved. In this study, we describe the collection of a cohort of rural UK samples (The People of the British Isles), aimed at providing a well-characterised UK-control population that can be used as a resource by the research community, as well as providing a fine-scale genetic information on the British population. So far, some 4000 samples have been collected, the majority of which fit the criteria of coming from a rural area and having all four grandparents from approximately the same area. Analysis of the first 3865 samples that have been geocoded indicates that 75% have a mean distance between grandparental places of birth of 37.3 km, and that about 70% of grandparental places of birth can be classed as rural. Preliminary genotyping of 1057 samples demonstrates the value of these samples for investigating a fine-scale population structure within the UK, and shows how this can be enhanced by the use of surnames.

http://www.nature.com/ejhg/journal/vaop/ncurrent/full/ejhg2011127a.html

Оффлайн CenturionАвтор темы

  • 100% Earth (Solar System) genofond
  • Администратор
  • *****
  • Сообщений: 10117
  • Страна: ru
  • Рейтинг +566/-2

The regions are: SW (Cornwall, Devon and Pembrokeshire), CN (Oxfordshire and the Forest of Dean), E (Sussex, Kent, Norfolk and Lincolnshire), N (Cumbria, Yorkshire and the North East) and OR (Orkney).

 

© 2007 Молекулярная Генеалогия (МолГен)

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