Population-genetic comparison of the Sorbian isolate population in Germany with the German KORA population using genome-wide SNP arrays // BMC Genetics 2011, 12:67doi:10.1186/1471-2156-12-67б Published: 28 July 2011
Gross et al.
The Sorbs are an ethnic minority in Germany with putative genetic isolation, making the population interesting for disease mapping. A sample of N=977 Sorbs is currently analysed in several genome-wide meta-analyses. Since genetic differences between populations are a major confounding factor in genetic meta-analyses, we compare the Sorbs with the German outbred population of the KORA F3 study (N=1644) and other publically available European HapMap populations by population genetic means. We also aim to separate effects of over-sampling of families in the Sorbs sample from effects of genetic isolation and compare the power of genetic association studies between the samples.
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