В материалах Международной конференции «Centenary of Human Population Genetics» (Москва, 29-31 мая 2019 г.) есть доклад:
Damba Larisa
Distribution of haplogroup N3a*-L708 in Siberian populations according to STR-haplotypes
Damba L., Romanov A., Olkova M.
Research Institute of Medical and Social Problems and Control of the Healthcare Department, Kyzyl,667000, Russia
Vavilov Institute of General Genetics Russian Academy of Sciences, Moscow,119991, Russia
Research Centre for Medical Genetics, Moscow,115478, Russia
Biobank of Northern Eurasia, Moscow,115201, Russia
Haplogroup N-M231 is widespread in Northern Eurasia from Scandinavia to the Far East. The branch of the haplogroup
N3a*-L708 (Ilumäe et al., 2016) is currently found only in Siberian populations.
The phylogenetic network of the N3a*-L708 in populations of Southern Siberia (Khakas Sagais, Kachins, Kyzyls, Abakan Shors,
mountain Shors, Central, Western, Northeast and Southern Tuvans) (own data), Western Siberia (Khanty and Komi) and Northeastern
Siberia (Yakut, Evenk and Dolgan) (Karafet et.al.,2018) was built and edited in programs Network 5.0.1.0. and Network
Publisher according to 8 STR-markers-DYS19, DYS 389a, DYS389b, DYS390, DYS391, DYS392, DYS393, DYS439 (DYS385 was
excluded from the analysis).
The analysis showed the separation the phylogenetic network of the N3a*-L708 into three ethnospecific clusters: Southern,
Western and Northeast Siberian. The greatest diversity of STR-haplotypes was found in the Southern Siberian cluster.
The phylogenetic network of the N3a*-L708 in the Western and Northeastern clusters shows a low genetic diversity of STR
haplotypes. It can be explained by the effect of gene drift in these populations and the small number of STR-markers included in
the analysis. We see the opposite picture in the Southern Siberian cluster-a fairly high STR-haplotype diversity. This conclusion
is confirmed by the phylogenetic network of the N3a*-L708 in the Southern Siberian cluster, which was constructed according
to 15 STR markers-DYS19, DYS389a, DYS389b, DYS390, DYS391, DYS392, DYS393, DYS437, DYS438, DYS439, DYS448,
DYS456, DYS458, DYS HATA_H4, DYS635 (DYS385 was excluded from the analysis) (own unpublished data).
The phylogenetic network of the N3a*-L708 in the populations of Southern Siberia has a rather complex structure and the high
diversity in these populations confirms the hypothesis of their local identity.
The estimate age of the N3a*-L708 according to the full genome sequencing is 7700+/-900 years (Ilumäe et al.,2016). The age
of the subclusters was calculated after the selecting Tuvan and Khakas-Shor-Tuvan subclusters and the choice of the proposed
founder haplotype in each sub-cluster (based on the number of “descendants”). The expected age of the Tuvan cluster was
8555+/-3540 years, and the Khakas-Shor-Tuvan cluster-4162+/-2017 years.
For a more complete understanding of the N3a*-L708 phylogeography of the populations of Siberia is necessary a more detailed
study with a large number of SNP and STR markers.