АвторТема: rs1800795  (Прочитано 4164 раз)

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rs1800795
« : 04 Май 2010, 09:58:00 »
Mind Over Matter?
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At the Chronicle of Higher Education, Helen Fields examines a  recent study, performed by Stephen Cole at the University  of California, Los Angeles, and his colleagues which identifies a  specific pathway wherein gene-social environment interactions directly  impact a patient's health. Using a bioinformatic strategy coupled with  an expression responsive array-based method to identify environmentally  responsive transcription factors, Cole and his collaborators predicted  that a single nucleotide polymorphism, rs1800795, at the human  interleukin 6 promoter might play a role in altering human health risk  based on stress from social adversity. IL6, which helps to promote the  inflammatory response, "is a problem if you make it all the time,"  leading to chronic inflammation, Fields writes. "It's almost like a  generic fertilizer for the diseases that most often kill us," Cole told the Chronicle. "Things like coronary  heart disease, the most prevalent kinds of cancer, neurodegenerative  diseases, probably Type 2 diabetes as well," are associated with chronic  inflammation. By first testing the models' predictions in a cell line  exposed to norepinephrine — to induce stress in the cells and,  ultimately, to cause GATA-1 transcription factor activation — and then  in a colleague's long-term cohort of older adults, Fields reports, the  team was able to confirm that those with "the nonmutated sequence were  twice as likely to die in the next 10 years." In effect, the rs1800795  mutation appears to protect those who have it. The team's next step,  Fields reports, is to examine "whether happiness might balance out  stress in the cells." Cole told the Chronicle that the teams'  largest remaining question is that "if people cannot or will not give up  stress, is there something we can do biologically to help?"

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Re: rs1800795
« Ответ #1 : 04 Май 2010, 10:01:14 »
Computational identification of gene–social environment interaction at the human IL6 locus Steven W. Cole, Jesusa M. G. Arevalo, Rie Takahashi, Erica K. Sloan, Susan K. Lutgendorf, Anil K. Sood, John F. Sheridan and Teresa E. Seeman
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To identify genetic factors that interact with social environments to  impact human health, we used a bioinformatic strategy that couples expression array–based detection of  environmentally responsive transcription factors with in silico  discovery of regulatory polymorphisms to predict genetic loci  that modulate transcriptional responses to stressful environments.  Tests  of one predicted interaction locus in the human IL6  promoter (SNP rs1800795) verified that it modulates transcriptional  response to ?-adrenergic activation of the GATA1 transcription factor in vitro. In vivo validation studies  confirmed links between adverse social conditions and increased  transcription of GATA1 target genes in primary neural, immune,  and cancer cells. Epidemiologic analyses verified the health  significance of those molecular interactions by documenting  increased 10-year mortality risk associated with late-life depressive  symptoms that occurred solely for homozygous carriers of the  GATA1-sensitive G allele of rs1800795. Gating of depression-related  mortality risk by IL6 genotype pertained only to  inflammation-related causes of death and was associated with increased  chronic inflammation as indexed by plasma C-reactive protein. Computational  modeling of molecular interactions, in vitro biochemical analyses, in vivo animal modeling, and human molecular  epidemiologic analyses thus converge in identifying ?-adrenergic  activation of GATA1 as a molecular pathway by which social adversity  can alter human health risk selectively depending on individual genetic  status at the IL6 locus.

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Re: rs1800795
« Ответ #2 : 04 Май 2010, 10:03:20 »
У кого какой rs1800795?
У меня GG
« Последнее редактирование: 04 Май 2010, 10:17:00 от mouglley »

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Re: rs1800795
« Ответ #3 : 04 Май 2010, 10:16:41 »
snpedia:
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The rs1800795(G) allele, generally associated with higher levels of IL6, has been associated with increased risk in the following studies:

    * The rs1800795(G) allele was significantly associated with type-2 diabetes (odds ratio 1.51, CI: 1.11-2.07, p=0.0096) in a study of 700 elderly Caucasians.[PMID 15472205]

    * Following a kidney transplant, patients with rs1800795(G;G) genotypes have a higher risk of new-onset diabetes and higher C-reactive protein levels) compared to the (C;C) genotype. Since this was more pronounced in overweight patients, the authors suggest that diabetes-inducing drug administration should be limited in overweight patients who are rs1800795(G;G) following renal transplantation.[PMID 16837641]

    * The development of bronchiolitis obliterans syndrome (BOS) after lung transplantation is more likely and happens earlier for rs1800795(G) carriers.[PMID 12451269]

    * Among HIV+ men, the lifetime risk of developing Kaposi sarcoma is higher for rs1800795(G;G) homozygotes compared to (C;C) homozygotes.[PMID 11001912]

    * Patients with Hodgkin's lymphoma who are rs1800795(G;G) were less likely to be successfully treated, with odds ratios for failure of 1.75 (CI: 1.04-2.92, p=0.03).[PMID 17496310]

    * A study of 139 elderly males with acute coronary syndrome (ACS) indicated that rs1800795(G;G) genotypes were at 3.89 fold (CI: 1.71-8.86, p=0.001) higher risk of dying within one year of their ACS event than (C;G) or (C;C) genotypes.[PMID 16098388]

    * Although the odds of having a stroke weren't different, among patients (in this case, under 60 years of age) who did have a stroke those with a rs1800795(G;G) genotype had more severe disability after 1 week (odds ratio 3.2, CI: 1.5-6.6, p=0.002).[PMID 14512079]

    * Among Chinese patients with hypertension, the rs1800795(G) allele is more common, and (G;G) genotypes had significantly higher plasma PAI-1 activity than (C;C) genotypes.[PMID 15831362]

    * In 168 Brazilian patients, rs1800795(G) allele frequency was higher in gastric cancer than in patients with chronic gastritis. [PMID 17560462]

    * Although the odds of having Crohn's disease aren't affected, among 153 children with it, those with the rs1800795(G;G) genotype were more growth-retarded at diagnosis than (C;G) or (C;C) genotypes. (G;G) patients also had higher circulating levels of C-reactive protein (CRP).[PMID 16150725]

    * rs1800795(G) carriers don't increase their high-density lipoprotein (HDL) levels after 24 weeks of aerobic exercise as much as rs1800795(C) carriers.[PMID 15904871]

    * The rs1800795(G;G) genotype was more frequent in Australian infants with sudden infant death syndrome (58%) than in control subjects (38%, p=0.02).[PMID 17055359] This was not seen in a Norwegian population.[PMID 17509454]

    * Women with endometriosis who are rs1800795(G) carriers appear to be more likely to develop chocolate cysts, and (G) allele carriers may be at slightly higher risk of developing endometriosis.[PMID 12517591]

    * The rs1800795(G) allele is more frequent in women with hyperandrogenism than in controls.[PMID 11889177]

    * Children with the rs1800795(G;G) genotype are more likely to have recurrent acute otitis, based on a study of 348 patients, with an odds ratio of 1.64 (p=0.02).[PMID 17908769]

    * (G) allele is increased risk ((C) allele is decreased risk) for type-2 diabetes; this SNP is one of 4 relatively common SNPs reported to represent risk for type-2 diabetes in the DESIR prospective study of 3,877 Caucasian participants. Under an additive model, the odds ratio for rs1800795(C) carriers is 0.79 (CI: 0.65-0.96, p=0.01). For the 4 SNPs, each risk allele increased type-2 diabetes risk by 1.34x (p=2x10e-6), with an odds ratio of 2.48 (CI: 1.59-3.86) for carriers of 4 or more compared to those with one or none (risk alleles).[PMID 17977958]
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The rs1800795(C) allele, generally  associated with lower levels of IL6, has been associated with increased  risk in these studies: 
  • rs1800795 (C;C) and (C;G)  Caucasians who are excessively heavy (body mass index ~33 +/- 5kg/m2)  are at increased risk (odds ratio 5.2, p=0.003) for developing  obesity-related metabolic disorders such as hypertension, atherogenic  dyslipidemia, and insulin resistance.[PMID 17998015]
  • Among 571 patients with type-2 diabetes, the rs1800795(C)  allele is correlated with higher body mass index, but it showed no  correlation among non-diabetics.[PMID 15172007]
  • A study of 238 Caucasians with type-2 diabetes concluded that rs1800795(C)  carriers have an insulin resistance "IL-6-sensitive" phenotype and  perhaps strategies to manage insulin resistance should be different  between (C) carriers vs. (G;G) patients.[PMID 16140413]
  • In patients with end-stage renal disease (ESRD) being treated  by hemodialysis, rs1800795(C) allele  carriers had higher diastolic blood pressure (p=0.008) and a higher left  ventricular mass index (p=0.026) than (G;G) homozygotes. Among diabetic  patients in dialysis, the prevalence of left ventricular hypertrophy in  (C) allele carriers was 87.5% vs. 36.3% among (G;G) genotypes (p=  0.02).[PMID 12846758]
  • Among recipient of a kidney transplant, rs1800795(C) allele carriers had worse  three-year graft survival (71/104 = 68.3%; p=0.0059) with a 3.7-fold  increased relative risk of graft loss compared to rs1800795(G;G) genotypes (48/54 = 88.9%). The  authors suggest that determining the rs1800795  genotype may offer a new method for identifying patients at increased  risk of allograft loss.[PMID 12371985]
  • Among prostate cancer patients, the rs1800795(C)  allele is associated with more aggressive cancer and higher  prostate-specific antigen levels compared to rs1800795(G;G)  homozygotes.[PMID 16006970]
  • Although the rs1800795(C)  allele was not associated with a higher frequency of heart attacks, it  did have an association with inflammation and infarcts detectable only  by MRI, suggesting that rs1800795(C)  may chronically predispose an individual to develop atherosclerosis.[PMID 12482836]
  • The combination of carrying at least one rs1800795(C) and one rs1205(T),  a SNP in the C-reactive protein gene, led to higher risk of a stroke  after cardiac surgery (odds ratio 3.3, CI: 1.4-8.1, p=0.0023) compared  to individuals who were rs1800795(G;G)  and rs1205(C;C).[PMID 16051899]
  • The rs1800795(C) allele was  associated with higher postoperative IL6 levels and a less favorable  clinical outcome following coronary revascularization surgery.[PMID 16183563]
  • The rs1800795(C;C) genotype  was significantly higher in the group of 122 adult periodontitis patients than in controls (odds  ratio 1.896, CI: 1.1-3.2, p=0.0283).[PMID 17209781]
  • The rs1800795(C) allele was  over-represented in patients with Alzheimer's disease compared to controls  and the (C;C) genotype was associated with higher risk in women.[PMID 12928051]
  • The rs1800795(C) allele was  higher in non-survivors compared to (nonagenarian) survivors in a  case/control study of ~100 pairs of matched Finnish individuals; to put  it another way, the rs1800795(G)  allele may be associated with increased longevity.[PMID 15664628]

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Re: rs1800795
« Ответ #4 : 04 Май 2010, 10:34:07 »
А можно кратко объяснить о чем речь?

Оффлайн mouglleyАвтор темы

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Re: rs1800795
« Ответ #5 : 04 Май 2010, 11:18:59 »
Разные значения - С или G в rs1800795 влияют на предрасположенность к разным заболеваниям.
В моём последнем посте текст со snpedia с названиями этих болячек на импортном.
От внезапной детской смерти и диабета, до нарушений сердечно-сосудистой.

К сожалению, с медицинскими терминами не знаком.

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Re: rs1800795
« Ответ #6 : 04 Май 2010, 12:18:37 »
У меня СС.
Пока все мимо, вернее то, что у них написано для СС у меня с точностью до наоборот (если я правильно перевела).
у них повышенная масса тела - у меня проблема набрать вес;
у них повышенное давление - у меня пониженное.
С остальными проблемами пока не сталкивалась :)

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Re: rs1800795
« Ответ #7 : 04 Май 2010, 13:15:47 »
У меня СС.

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Re: rs1800795
« Ответ #8 : 04 Май 2010, 13:33:35 »
GG    :)
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the rs1800795(G)  allele may be associated with increased longevity

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Re: rs1800795
« Ответ #9 : 04 Май 2010, 16:01:11 »
У меня CG.
У троюродного брата CC.

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Re: rs1800795
« Ответ #10 : 04 Май 2010, 21:53:56 »
У меня CG.
У троюродного брата CC.

У меня - точно так-же: CG.
(Может быть - по общему ареалу проживания одной из Вашей и одной из моих веток? У меня - почти граница Владимирской с Рязанской обл., у вас - то-же, но со стороны Рязанской обл., т.е. почти пешеходные расстояния).
Надо-бы посмотреть - нет ли там у нас общего УПСа).

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Re: rs1800795
« Ответ #11 : 04 Май 2010, 22:11:44 »
Один снип ничего не значит в генеалогических расчетах. По существу, медицинские ассоциации одного снипа также малозначимы, т.к. для вычисления медицинских рисков даже по одному заболеванию зачастую необходимо принимать данные по ассоциациям десятков, если не сотен, снипов.

 

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