АвторТема: Gene for recombination rates  (Прочитано 1439 раз)

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Gene for recombination rates
« : 07 Сентябрь 2010, 06:09:51 »
Gene for recombination rates
Implications for health and ancestry:

""Our new study has focused on a gene called PRDM9 that makes a protein which binds to DNA and triggers hotspot activity. The exciting finding is that people with different versions of PRDM9 show profoundly different recombination behaviours, not only in hotspots but also in chromosomal rearrangements that cause some genetic disorders."
Ironically, the variation in PRDM9 is due to a minisatellite within the gene itself. Sir Alec said: 'I've come full circle -- starting out with minisatellites to develop DNA fingerprinting, and arriving at a gene containing a minisatellite that plays a key role in driving all kinds of human DNA diversity, including variation at minisatellites. An intriguing possibility is that it is even driving its own evolution!'"



© 2007 Молекулярная Генеалогия (МолГен)

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