Пять новых гаплогрупп мтДНК найдено в Китае благодаря накоплению большой статистики - 6093 образца от 84 популяций.
Large-scale mtDNA screening reveals a surprising matrilineal complexity in East Asia and its implications to the peopling of the region
Qing-Peng Kong1,2,*, Chang Sun1, Hua-Wei Wang3, Mian Zhao1,2, Wen-Zhi Wang1,2, Li Zhong3, Xiao-Dan Hao1,2, Hui Pan1,2, Sha-Yan Wang4, Yao-Ting Cheng1,2, Chun-Ling Zhu1, Shi-Fang Wu1, Li-Na Liu1, Jie-Qiong Jin1, Yong-Gang Yao5 and Ya-Ping Zhang1,2,3,*
1 State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
2 KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming 650223, China
3 Laboratory for Conservation and Utilization of Bio-resource, Yunnan University, Kunming 650091, China
4 Shenzhen People's Hospital, Clinical Medical College of Jinan University, Shenzhen 518020, China
5 Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
* Address for correspondence and reprints: Dr. Qing-Peng Kong E-mail:
kongqp@yahoo.com.cn, Tel: +86 0871-519 7967, Fax: +86 0871-519 7967, or Dr. Ya-Ping Zhang, E-mail:
zhangyp@mail.kiz.ac.cn, Tel: +86 0871-519 0761, Fax: +86 0871-519 5430
Received for publication March 4, 2010. Accepted for publication August 10, 2010.
In order to achieve a thorough coverage of the basal lineages in the Chinese matrilineal pool, we have sequenced the mitochondrial DNA (mtDNA) control region and partial coding-region segments of 6,093 mtDNAs sampled from 84 populations across China. By comparing with the available complete mtDNA sequences, 194 of those mtDNAs could not be firmly assigned into the available haplogroups. Completely sequencing 51 representatives selected from these unclassified mtDNAs identified a number of novel lineages, including five novel basal haplogroups that directly emanate from the Eurasian founder nodes (M and N). No matrilineal contribution from the archaic hominid was observed. Subsequent analyses suggested that these newly identified basal lineages likely represent the genetic relics of modern humans initially peopling East Asia, instead of being the results of gene flow from the neighboring regions. The observation that most of the newly recognized mtDNA lineages have already differentiated and show the highest genetic diversity in southern China provided additional evidence in support of the Southern-Route peopling hypothesis of East Asians. Specifically, the enrichment of most of the basal lineages in southern China and their rather ancient ages in Late Pleistocene further suggested that this region was likely the genetic reservoir of modern humans after they entered East Asia.
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Тема: Пять новых гаплогрупп найдено в Китае (Прочитано 2067 раз)