DeCodeMe

[mouglley]

Announcing the New deCODE

Reykjavik, ICELAND, January 21, 2010 – deCODE genetics ehf today emerged as a newly financed, private company focused on advancing the science of human genetics and its application to products and services that improve human health. The new company will be building on the scientific leadership in genetics it developed over more than a decade as a subsidiary of deCODE genetics, Inc. deCODE ehf was this week purchased from its former parent company by Saga Investments LLC, a consortium that includes Polaris Ventures and ARCH Venture Partners, two leading life science investors. deCODE will continue all of its operations and product lines in this field, including its deCODE diagnostics disease risk tests; deCODEme™ personal genome scans; and contract service offerings including genotyping, sequencing and data analysis. Going forward, deCODE  will concentrate on translating its science into medically and commercially important products and services.  The company will be led by a two-man executive committee comprised of Earl “Duke” Collier, previously an executive vice president at Genzyme Corp.,who will serve as CEO, and Kari Stefansson, who will serve as executive chairman and president of research.

[napobo3]

Цена теста (1 млн снипов) подскочила с 985 до 2000$

[Mich Glitch]

Халява, похоже, кончилась окончательно.
Мои введённые от 23эндМи данные исчезли.
Любезно предлагают заплатить 2000 денег.
Жаль, а я то думал, что эта музыка будет звучать вечно. ©

[Yulita]

Халява, похоже, кончилась окончательно.
Мои введённые от 23эндМи данные исчезли.
Любезно предлагают заплатить 2000 денег.
Жаль, а я то думал, что эта музыка будет звучать вечно. ©

Меня пока не удалили.

[Mich Glitch]

Халява, похоже, кончилась окончательно.
Мои введённые от 23эндМи данные исчезли.
Любезно предлагают заплатить 2000 денег.
Жаль, а я то думал, что эта музыка будет звучать вечно. ©

Меня пока не удалили.

Раньше вошёл - раньше вышел.

Не скажу, чтобы расстроился слишком сильно.
Главное - сравнительная база, а у ДекодМи её можно сказать и нет почти.

[mouglley]

По-моему, я эмигрировал туда один из первых и до сих пор там.

[Mich Glitch]

По-моему, я эмигрировал туда один из первых и до сих пор там.

Ну, не знаю.
Может редко захаживал.
Может просто какой сбой.
Но учетная запись есть с кучей друзей, а крутящиеся картинки больше посмотреть не могу.
Да, и ладно.

[I2a1a]

В конце октября этого года deCODEme опубликовала 6 новых генетических карт (в зависимости от пола и carrier-status),  а также 9 новых карт рекомбинации

http://www.decode.com/addendum/

Six genetic maps and nine standarized recombination maps are provided below.  The carrier and noncarrier nomenclature refer to carriers and noncarriers of the composite PRDM9 14/15 repeat allele. Research using any of these fifteen maps should cite:  Kong, A et al.  Fine scale recombination rate differences between sexes, populations and individuals. Nature  467 , 1099–1103 (28 October 2010) doi:10.1038/nature09525.

Genetic maps: (click link to download)

female.gmap
female_noncarrier.gmap
female_carrier.gmap
male.gmap
male_noncarrier.gmap
male_carrier.gmap

Standardized recombination maps: (click link to download)

female.rmap
female_noncarrier.rmap
female_carrier.rmap
male.rmap
male_noncarrier.rmap
male_carrier.rmap
sex-averaged.rmap
sex-averaged_noncarrier.rmap
sex-averaged_carrier.rmap

(click here to download a compressed .zip package with all fifteen maps and a README file)

 

Genetic Maps

Female (female.gmap, female_noncarrier.gmap, female_carrier.gmap) and male (male.gmap, male_noncarrier.gmap, male_carrier.gmap) genetic maps are provided.  Note that female maps also contain genetic distances for the X chromosome.

Each file has a column header:

    * chr - chromosome
    * snp - SNP
    * pos - base position of SNP in Build 36 coordinates
    * cM  - the estimated centiMorgan distance between this and the previous SNP (rounded to six decimal digits)

Although all of the SNPs used to construct the maps are listed, for each chromosome genetic distances are only estimated up to 2.5 Mb from the ends of the SNP coverage. SNPs in the end regions have their cM entries listed as NA.

 

Standardized Recombination Maps

Female (female.rmap, female_noncarrier.rmap, female_carrier.rmap), male (male.rmap, male_noncarrier.rmap, male_carrier.rmap) and sex-averaged (sex-averaged.rmap, sex-averaged_noncarrier.rmap, sex-averaged_carrier.rmap) standardized recombination maps are provided for the autosomes. The sex-averaged maps are the standardization of the average of the male and female maps.

Each file has a column header:

    * chr - chromosome
    * pos - base position of the 10 kb bin midpoint in Build 36 coordinates
    * seqbin - 1 if the bin contains no unsequenced regions; 0 otherwise
    * stdrate - standardized recombination rate for the bin (standardization is done with respect to the bins that contain no unsequenced regions - thus, although all bins have a standarized rate, the average rate is one for the 244,446 bins with no unsequenced regions) (rates are rounded to six decimal digits)

Regions less than 5 Mb from the ends of the SNP coverage are not included
.

[I2a1a]

Из абстракта статьи.

Meiotic recombinations contribute to genetic diversity by yielding new combinations of alleles. Recently, high-resolution recombination maps were inferred from high-density single-nucleotide polymorphism (SNP) data using linkage disequilibrium (LD) patterns that capture historical recombination events. The use of these maps has been demonstrated by the identification of recombination hotspots and associated motifs, and the discovery that the PRDM9 gene affects the proportion of recombinations occurring at hotspots. However, these maps provide no information about individual or sex differences. Moreover, locus-specific demographic factors like natural selection can bias LD-based estimates of recombination rate. Existing genetic maps based on family data avoid these shortcomings, but their resolution is limited by relatively few meioses and a low density of markers. Here we used genome-wide SNP data from 15,257 parent–offspring pairs to construct the first recombination maps based on directly observed recombinations with a resolution that is effective down to 10 kilobases (kb). Comparing male and female maps reveals that about 15% of hotspots in one sex are specific to that sex. Although male recombinations result in more shuffling of exons within genes, female recombinations generate more new combinations of nearby genes. We discover novel associations between recombination characteristics of individuals and variants in the PRDM9 gene and we identify new recombination hotspots. Comparisons of our maps with two LD-based maps inferred from data of HapMap populations of Utah residents with ancestry from northern and western Europe (CEU) and Yoruba in Ibadan, Nigeria (YRI) reveal population differences previously masked by noise and map differences at regions previously described as targets of natural selection.

[Valery]

Запрещено оставлять сообщения

Так и до восстановления смертной казни дойдет 

[Овод]

Дойдёт, если и дальше все прочитанные посты метить будет.

[Centurion]

Запрещено оставлять сообщения

Так и до восстановления смертной казни дойдет 

мне кажется как-то странно, когда вдруг человек начинает ставить в 10-15 темах вместо сообщения смайл

[Valery]

Бывает подходит человек к кассе и вдруг начинает мычать, кассирша вопит, очередь хихикает  и тут выясняется что человек не стебется а он просто глухонемой

Вот так.

[I2a1a]

Бывает подходит человек к кассе и вдруг начинает мычать, кассирша вопит, очередь хихикает  и тут выясняется что человек не стебется а он просто глухонемой

Вот так.

Так вроде не глухонемой.

[Valikhan]

Это веснаааа.