Gene polymorphism of the renin-angiotensin system in six ethnogeographic regions of Belarus
L. N. Sivitskaya1 , E. I. Kushniarevich1, N. G. Danilenko1, T. A. Novogrodski2 and O. G. Davydenko1
(1) Institute of Genetics and Cytology, National Academy of Sciences of Belarus, Minsk, 220072, Belarus
(2) Department of Ethnology, Belarusian State University, Minsk, 220030, Belarus
Received: 26 April 2007 Published online: 23 May 2008
Abstract The insertion/deletion polymorphism of the angiotensin-converting enzyme gene (ACE) and the T174M polymorphism of the angiotensinogen gene (AGT) have been studied in six ethnogeographic regions of Belarus. Significant intrapopulation differences in ACE genotype frequencies have been found for the northern and eastern regions (the Dvina and Dnepr basins, respectively). Significant differences in the AGT genotype frequencies have been found between populations of the Dnepr basin and populations of all other Belarusian regions. The allele and genotype frequencies of the genes studied in the Belarusian population and populations of other regions of the world have been compared. The frequencies of the insertion (I) and deletion (D) alleles of the ACE gene in the Belarusian population are 50.7 and 49.3%, respectively, which is similar to these frequencies in European countries. The frequency of the M allele of the AGT gene in Belarus is 16.6%, which is higher than its frequency in populations of European, African, and Asian origins.
Original Russian Text © L.N. Sivitskaya, E.I. Kushniarevich, N.G. Danilenko, T.A. Novogrodski, O.G. Davydenko, 2008, published in Genetika, 2008, Vol. 44, No. 5, pp. 702–709.